IPS Profile for Internal Segmentation

Hello Everyone,

i am designing a new Internal Segmentation Projekt and wondering about IPS Profile Signatures that should be used for internal traffic.

for Example for Traffic

ClientA > ClientB   = here would you use Windows Server Signatures to protect ClientB ? as a client can also use and share some Server Services ?

Server > Client  = which signatures would you use here?

Server > Internet  = here i would set client Signatures only as i want to protect the Server

would appreciate your thoughts and ideas for using IPS Profiles in Internal Segmenation

Thank you