Adding some info here:
You will want to enable AV as well as Web Filtering, blocking the " Security Risk" category. You may also want to block Botnet under your AV profile, as well as under an Application Security Profile.
There are several improvements in FortiOS 5.2 related to Antivirus, please consider upgrading your installation to the latest patch.
Also, in 5.2 the " flow" method is much improved to the point where it is as effective (or nearly so) to proxy mode. This gives you a healthy boost in performance and capacity since AV is one of the hardest hitting protections on the box. Please consider using flow mode for all of the UTM profiles you enable.
You might also consider enabling grayware detection if that is important to you:
config antivirus settings
set grayware enable
end
Hope this helps. Cheers!
--
Sean Toomey, CISSP FCNSP
Consulting Security Engineer (CSE)
FORTINET— High Performance Network Security