Hi,
We also have a 1000C with explicit proxy, 2000 + users at the moment, and have that happen sometimes, however it did not happen in the last week or 2, after, we believe, changing a setting on our FSSo collectors (2). The slowness always seemed to relate to FSSO somehow.
Clearing Groupo cache seemend to solve it every time, and/or Clear user cache
We set the timers, on the FSSO Agent configuration Gui, to :
Wkst verify int : 15 but 5 is also ok
Dead entry timeout : 240 but 480 is also ok
IP address change verify : 60
and Cache user group lookup, expire : 5 minutes
Seems to wotk for us.
In the same group, people on one DC/Domain had fast Internet, and others were slow, no visible reason, and seems ok now.
Probably would' nt hurt much to try, maybe during lunch or after hours?