This packet itself is not a clear indication of an issue. It just shows the client is trying to open a new TCP session and that the packet capture already contains previous session with the same port numbers. It does not indicate why was the previous session closed.
The only wild guess I can take is that this could potentially be caused by session clashes, when for instance, you have multiple clients behind SNAT connecting to the same proxy.
You should also investigate on your EDU_Proxy server to see why exactly are the sessions being reset.
Since you have multi-vdom setup, transparent proxy and proxy forwarding in place, the debugging can get rather complex. You should really create a TAC support ticket with a detailed network diagram.
Questions should also be raised on whether such complex setup is actually needed ;-).