So I finally took the time to try WAN Optimization between two FortiGate' s.  Both are 60C' s with 32 GB Class 10 SD cards installed, and 29 GB provisioned for WAN Optimization storage space.  There are Windows servers at each site with SMB file shares.  I did a rule set on each site to cache traffic requested by client PCs to the servers on each side.  I made two rules: one for port 445, which I think was enough, but just in case I also made one for 49152-65535, which is the random port range Server 2008/Vista+ use in conjunction with port 445.  The results were fairly immediate and somewhat impressive.  Downloading a 30 MB file will take 10 mins the first time, and only ~1 minute the second time - peaking at 2 MB/s file transfer versus maybe 40 KB/s for a non-cached file.  However, I do notice increased latency versus before, so I' m reluctant to roll out optimization to the server to server traffic (the servers seem to use 445 for a lot of communication) and to traffic outside of CIFS/SMB.
 
 I do think this has great potential but the Fortinet docs and knowledge base are lacking on examples for site-to-site traffic optimization (e.g., generic TCP optimization mentioned in the " Inside FortiOS"  sheet but totally absent in any examples).  If people are interested in my rule sets that I got to work I' d be happy to share them, and conversely I' d love to hear from others that have deployed WAN Optimization and where it is benefiting them.