Potential issues with setting MTU size of 9216?

[simonorch]

Does anyone know of any potential negatives with increasing MTU frames size to 9216 for internal traffic (ie. not internet bound)?

This is on a 2000E running 6.0.x and LAG interfaces with about 15 vdoms

i'm thinking in terms of content processing, np offloading etc. i know NP6 supports it

off the face of it i can think of potential benefits if it reduces the number of frames 

Simon