There is a possibility of the FortiClient application firewall blocking DNS resolution from FortiClient to EMS cloud FQDN, forticlient-emsproxy.forticloud.com if the application firewall is enabled in the application firewall endpoint profile and if an EMS administrator has configured to block the entire Network.Service category.
When this situation happens, FortiClient's telemetry enters into 'Not reachable' state.

To verify if it is a DNS resolution issue, review FortiESNAC error logs and it will indicate that FortiClient failed to resolve server address 'fct-FCTUID-tokencode-8013.forticlient-emsproxy.forticloud.com' as below:
[2025-03-24 09:58:36.3480588 UTC+08:00] [1324:1396] [FortiESNAC 974 error] Could not contact the current server - backing up server address and trying other available servers [2025-03-24 09:59:18.7873487 UTC+08:00] [1324:1396] [FortiESNAC 269 error] Failed to resolve server address fct-FCTUID-tokencode-8013.forticlient-emsproxy.forticloud.com(11001): No such host is known. [2025-03-24 09:59:18.7875012 UTC+08:00] [1324:1396] [FortiESNAC 974 error] Could not contact the current server - backing up server address and trying other available servers [2025-03-24 10:01:11.2574916 UTC+08:00] [1324:6252] [FortiESNAC 332 error] Failed to upload quarantined files [2025-03-24 10:02:15.3751890 UTC+08:00] [1324:1396] [FortiESNAC 269 error] Failed to resolve server address fct-FCTUID-tokencode-8013.forticlient-emsproxy.forticloud.com(11001): No such host is known. [2025-03-24 10:02:15.3753343 UTC+08:00] [1324:1396] [FortiESNAC 974 error] Could not contact the current server - backing up server address and trying other available servers [2025-03-24 10:02:57.9213137 UTC+08:00] [1324:1396] [FortiESNAC 269 error] Failed to resolve server address fct-FCTUID-tokencode-8013.forticlient-emsproxy.forticloud.com(11001): No such host is known. [2025-03-24 10:02:57.9214414 UTC+08:00] [1324:1396] [FortiESNAC 974 error] Could not contact the current server - backing up server address and trying other available servers [2025-03-24 10:03:40.9870433 UTC+08:00] [1324:1396] [FortiESNAC 269 error] Failed to resolve server address fct-FCTUID-tokencode-8013.forticlient-emsproxy.forticloud.com(11001): No such host is known. [2025-03-24 10:03:40.9873230 UTC+08:00] [1324:1396] [FortiESNAC 974 error] Could not contact the current server - backing up server address and trying other available servers
To resolve this issue, in Endpoint Profiles -> Application Firewall -> Edit the affected firewall profile -> Application Overrides, add DNS application signature and set Action to Allow in Application Overrides as shown below:

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